Diffuse light increases metabolic activity in the lateral geniculate nucleus, visual cortex, and superior colliculus of the cone-dominated ground squirrel visual system

Ground squirrels were monocularly exposed to either steady- or flashing-diffuse light for 45 min following an injection of 14C 2-deoxyglucose (2-DG). Autoradiographic analysis indicated greater metabolic activity in the lateral geniculate nucleus, visual cortex and superior colliculus (SC) of the hemisphere lying contralateral to and receiving input from the diffusely stimulated eye (covered by a white mask), than in the corresponding regions of the other hemisphere receiving input from the occluded eye (black mask). The diffuse light results for the cortex and colliculus of the diurnal ground squirrel are different from those for the nocturnal rat. In the rat visual cortex, there is no difference between metabolic activity under conditions of diffuse light (steady or flashing) and under darkness. In the rat SC, although flashing-diffuse light increases metabolic activity (as is the case for the squirrel), steady-diffuse light decreases it to a level below that which occurs in darkness. The cortex and colliculus differences in 2-DG response to diffuse light between the ground squirrel and rat were attributed to differences in the operations of their respective cone- and rod-dominated visual systems.